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Análise das Proteínas Envolvidas na Angiogênese em Desordens Potencialmente Malignas e no Carcinoma Espinocelular

DOI: http://dx.doi.org/10.15602/1983-9480/cmrs.v17nespp31-45

https://www.metodista.br/revistas/revistas-ipa/index.php/RS/index 

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Carlos A. N. Bernardes1, Leonardo F. Diel1, Alessandra Magnusson1, Lisiane Bernardi1 & Marcelo L. Lamers1

 

Resumo: O carcinoma espinocelular é responsável por 90% das lesões orais. Os carcinomas podem se desenvolverde células epiteliais normais ou de desordens potencialmente malignas(hiperplasias e displasias). Para que estas lesões se desenvolvam é necessária a formação de novos vasos. Este processo, denominado angiogênese, envolve a regulação de diferentes fatores, como Angiopoetina1 e Trombospondina1, que podem ser influenciadas pelas células epiteliais ecomponentes do microambiente da lesão. Nosso objetivofoi descrever a expressão de angiopoetina1 e trombospondina1 em biópsias de desordens potencialmente malignas e em carcinoma espinocelular oral.A amostra composta por biópsias de hiperplasia, displasia eca r c i noma. As lâminas f oram submetidas àimunoistoquímica.Foi analisada da marcaçãoemtecido epitelial econjuntivo. Angiopoetinamarcounas células endoteliaiscom leve marcação nas células da camada basal do epitélio, sendo observada uma redução da intensidade de marcação com aumento daseveridade, aumentando em células do microambiente tumoral. Trombospondina marcouheterogeneamentenos tecidos, com um aumento da marcação em macrófagos e fibroblastos de acordo com a severidade da lesão. O perfil diferenciadodestes marcadores em células epiteliais modificadas e em células do microambiente celular evidencia a necessidade de mais estudos que explorem a diversidade celular destas lesões, para aprimorar as terapias anti-angiogênicas.

Palavras-chave: Angiopoetina, Trombospondina, Displasia, microambiente tumoral.

 

1 Faculdade de Odontologia da Universidade Federal do Rio Grande do Sul.

 

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