Купить СНПЧ А7 Архангельск, оперативня доставка

crosscheckdeposited

Repercussões do Estresse Oxidativo Sistêmico na Doença Pulmonar Obstrutiva Crônica

DOI: http://dx.doi.org/10.15600/2238-1244/sr.v12n31p69-76

https://www.metodista.br/revistas/revistas-unimep/index.php/saude/index 

downloadpdf

Viviane G. Joaquim1 & Eli M. P. Forti2

 

Resumo: Repercussões do estresse oxidativo sistêmicoA doença pulmonar obstrutiva crônica (DPOC) e uma das principais causas de mortalidade e morbidade a nível mundial. O tabaco continua sendo o principal fator de risco para o desenvolvimento da doença, e recentemente o processo inflamatório tem sido considerado um dos principais responsáveis pela progressão continua e irreversível da DPOC. Tendo em vista as repercussões negativas da DPOC, o objetivo deste estudo será abordar as alterações na estrutura (hiperinsuflacao) e na função pulmonar (redução do VEF1) como causas das manifestações locais da doença, e as anormalidades nutricionais e disfunção muscular periférica como causas das manifestações sistêmicas da doença. Desta forma, a DPOC deve ser considerada uma doença sistêmica, onde a partir desse ponto de vista, a fisioterapia possa contribuir para o tratamento global do paciente com DPOC e consequentemente com a melhora de sua qualidade de vida. O trabalho desenvolveu-se por meio de um estudo descritivo, realizado a partir de uma revisão bibliográfica na doença pulmonar obstrutiva crônica.

Palavras-chave: tabagismo; doença pulmonar obstrutiva crônica; inflamação; estresse oxidativo; qualidade de vida.

 

Abstract: Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality worldwide. Tobacco remains the leading risk factor for the development of the disease and the inflammatory process has recently been considered a major contributor to the ongoing and irreversible progression of COPD. Given the negative impact of COPD, the goal of this study will address the changes in the structure (hyperinflation) and pulmonary function (FEV1 reduction) as causes of the local manifestation of the disease, and nutritional abnormalities and peripheral muscle dysfunction as causes of systemic manifestations of the disease. Thus, COPD should be considered a systemic disease, which from that point of view, physical therapy may contribute to the overall treatment of patients with COPD and consequently to improve their quality of life. The work was developed through a descriptive study from a literature review.

Key words: smoking, chronic obstructive pulmonary disease, inflammation, oxidative stress, quality of life.

 

1 Fisioterapeuta e aluna do curso de pósgraduação em Fisioterapia Cardiorrespiratória da Universidade Metodista de Piracicaba- UNIMEP, E-mail: vivigerace@hotmail.com.
2 Professora do Curso de Graduação e Mestrado em Fisioterapia. Coordenadora do Curso de Especialização em Fisioterapia Cardiorespiratória da Universidade Metodista de Piracicaba, UNIMEP. E-mail: empforti@unimep.br.

 

Literatura Citada

World Health Organization. COPD predicted to be third leading cause of death in 2030. [internet] 2008. (Acesso em: 20 mar 2010). Disponível em: http://www.who.int/respiratory/copd/World_Health_Statistics_2008/en/index.html.

Dados do Ministério da Saúde sobre DPOC. (Acesso em: 07 nov 2011). Disponivel em: http://www2.datasus.gov.br/DATASUS/index.php/2008.

Wouters EFM. Local and systemic inflammation in chronic obstructive pulmonary disease. Proc. Am. Thorac. Soc. 2005; 2: 26-33.

Dourado VZ, Tanni SE, Vale AS, Faganello MM, Sanchez FF, Godoy I. Manifestações sistêmicas na doença pulmonar obstrutiva crônica. J Bras Pneumol. 2006; 32(2):161-71.

Dourado VZ, Godoy I. Recondicionamento muscular na DPOC: principais intervenções e novas tendências. Rev Bras Med Esporte. 2004; 10(4):331-334.

Casanova C, Cote C, Torres JP, Aguirre-Jaime A, Marin JM, Pinto-Plata V et al. Inspiratory-to-total lung capacity ratio predicts mortality in patients with chronic obstructive pulmonary disease. Am. J Respir Crit Care Med. 2005; 171: 591-7.

Garrod R, Marshall J, Barley E, Fredericks S, Hagan G. The relationship between inflammatory markers and disability in chronic obstructive pulmonary disease (DPOC). Prim Case Resp Journal. 2007; 20: 12-15.

Van Helvoort HAC, Heijdra YF, Boer RCC, Swinkels A, Thijs HMH, Richard DPN. Six-Minute Walking-Induced Systemic Inflammation and Oxidative Stress in Muscle-Wasted COPD Patients. Chest. 2005; 131:439-445.

Finucane KE, Panizza JA, Sing B. Efficiency of the normal human diaphragm with hyperinflation. J Appl Physiol. 2005; 99: 1402-11.

O’Donnell DE. Hyperinflation, dyspnea, and exercise intolerance in chronic obstructive pulmonary disease. Proc Am Thorac Soc. 2006; 3: 180-4.

Rufino R, Lapa SJR. Bases celulares e bioquímicas da doença pulmonar obstrutiva crônica. J Bras Pneumol. 2006; 32(3):241-8.

Barnes PJ. Immunology of asthma and chronic obstructive pulmonary disease. Nat Rev Immunol. 2008; 8(3):183-92.

Gold. Global Initiative for Chronic Obstructive Lung Disease. Global strategies for the diagnosis, management, and preventionof COPD. Am J Respir Crit Care Med. 2007; vol 176. pp. 532-555.

Walter R, Wilk J, Larson MG, Vasan RS, Keaney JF, Lipinska I, et al. Systemic Inflammation and COPD: The Framingham Heart study. Chest. 2008; 133(1): 19-25.

Aronson D, Roterman I, Yigla M, Kerner A, Avizohar O, Sella R, et al. Inverse Association betweenPulmonary Function and C-Reactive Protein in Apparently Healthy Subjects. Am J Respir Crit Care Med. 2006; 174 (6): 626-32.

Sin DD, Man SF. Why are patients with chronic pulmonary obstructive disease at increased risk of cardiovascular diseases? The potential role of systemic inflammation in chronic pulmonary obstructive disease. Circulation. 2003;107(11): 1514-9.

Higashimoto Y, Yamagata Y, etal. Systemic inflammation in chronic obstructive pulmonary disease and asthma: Similarities and differences. Respirology. 2008;13(1): 128-133.

Calabrese F, Baraldo S, Bazzan E, Lunardi F, Rea F, Maestrelli P, et al. IL-32, A Novel Proinflammatory Cytokine in Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2008; 178: 894-901.

Campos H. Doença Pulmonar Obstrutiva Crônica: mais do que apenas uma doença pulmonar. Bol Pneumol Sanit 2006;14(1):27-32.

Macnee W. Pulmonaryand systemic oxidant/antioxidant imbalance in chronic obstructive pulmonarydisease. Proc Am Trorac Soc. 2005; 2(1):50-60.

Godoy I, Castro SMH, Togashi RH, Geraldo RCC, Campana AO. Is chronic hypoxemia in patients with chronic obstructive pulmonary disease associated with more marked nutritional deficiency? A study of fat free mass evaluated by anthropometry and bioelectrical impedance methods. J Nutr Health Aging. 2000; 4: 102-8.

Hugli O, Fitting JW. Alterations in metabolism and body composition in chronic respiratory disease. Eur Respir J Monograph. 2003; 8:11-22.

Wagner, P. D. Possible mechanisms underlying the development of cachexia in COPD Eur Respir J 2008; 31: 492.

Broekhuizen R, Wouters EFM, Creutzberg EC, Schols AMWJ. Raised CRP levels mark metabolic and functional impairment in advanced COPD. Thorax. 2006; 61:17-22.

Cavicchia PP, Steck SE, Hurley TG, Hussey JR, MAY, Ockene IS, et al. A new dietary inflammatory index predicts interval chances in serum high-sensitivity c-reative protein. J Nutr. 2009;139:2365-72.

Eagan TML, Ueland T, Wagner PD, Hardie JA, Mollnes TE, Damas JK, Aukrust P, Bakke PS. Systemic inflammatory markers in COPD: results from the Bergen COPD Cohort Study Eur Respir J. 2010 35: 540-8.

Nici L, Donner C, Wouters E, Zuwallack R, Ambrosino N, Bourbeau J, et al. American Thoracic Society/ European Respiratory Society statement on pulmonary rehabilitation. Am J Respir Crit Care Med. 2006; 173(12):1390-413.

Troosters T, Casaburi R, Gosselink R, Decramer M. Pulmonary rehabilitation in chronic obstructive pulmonary disease - State of the Art. Am J Respir Crit Care Med. 2005; 172:19-38.

Augustí AGN, Morlá M, Sauleda J, Saus C, Busquets X. NF-κB activation and iNOS upregulation in skeletal muscle of patients with COPD and low body weight. Thorax 2004; 59:483-7.

Eid AA, Ionescu AA, Nixon L, Lewis-Jenkins V, Matthews SB, Griffiths TL, Shale DJ. Inflammatory response and body composition in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2001; 64:1414-8.