Купить СНПЧ А7 Архангельск, оперативня доставка

crosscheckdeposited

Stem Cells for the Treatment of Complex Regional Pain Syndrome (CRPS)/Reflex Sympathetic Dystrophy (RSD): A Case Study

DOI: http://dx.doi.org/10.18073/2358-4696/pajmt.v1n2p89-92

http://www.abraterm.com.br/revista/index.php/PAJTM/index 

downloadpdf

Robert G. Schwartz1

  

Abstract: Recently the literature has included numerous articles on the miracle of stem cells.   In clinical practice today the most common indication is for joint space narrowing however several other benefits including angiogenesis and peripheral nerve regeneration have been reported. This case report reviews a patient with Stage 3 RSD who suffered from chronic tropic skin changes after post fracture care. Cold stress thermographic imaging following American Academy of Thermology Guidelines for NeuroMusculoskelatal Thermology was performed to establish the distribution of vasomotor change and then autologous, adult stem cells were harvested and implanted into the calf as a result of the findings.   Within weeks allodynia and trophic changes dramatically improved.  The author concludes that Stem Cell Grafting is a viable alternative in the treatment of RSD and that cold stress thermograpic imaging is an invaluable tool to help define the type and distribution of vasomotor instability.

Key words: thermography, stem cells, sympathetic response, reflex sympathetic distrophy

 

Resumo: Recentemente, a literatura publicou inúmeros artigos sobre o potencial das célulastronco. Mas hoje na prática clínica a indicação mais comum é na redução do espaço intraarticular provocada pela osteoartrite apesar de vários outros benefícios, como angiogênese e regeneração de nervos periféricos também têm sido documentadas. Este é o relato de caso de um paciente com distrofia simpático-reflexa (DSR) estágio 3 que sofriam de alterações cutâneas crônicas pós fratura. Foi realizado estudo termográfico com teste ao estímulo frio de acordo com as orientações da Academia Americana de Termologia para Avaliação Neuromusculoesquelética para estabelecer a distribuição das mudanças vasomotoras depois da utilização autóloga de células-tronco adultas colhidas e implantadas na panturrilha. Em algumas semanas a alodínia e as alterações tróficas melhoraram dramaticamente. O autor concluiu que o enxerto com células tronco é uma alternativa viável para o tratamento da DSR e que o estudo termográfico com teste ao estímulo frio é um meio valioso para auxiliar definir o tipo e distribuição da instabilidade vasomotora.

Palavras-chave: termografia, células tronco, resposta simpática, distrofia simpática reflexa

 

1 Piedmont Physical Medicine & Rehabilitation, PA / e-mail: rgsheal@aol.com

 

Literatura Citada

Wilson PR, Stanton-Hicks M, Harden NR. CRPS: Current Diagnosis and Therapy. Seattle, IASP Press, 2005.

Schwartz R. Resolving Complex Pain, Morrisville. LuLu Press, 2006

Lee M, Cohen, J. Editors. Rehabilitation Medicine and Thermography. New York University Medical Center. Wilsonville, Impress Publications, 2008.

Ting Z, et al. Bone marrow-derived mesenchymal stem cells promote growth and angiogenesis of breast and prostate tumors. Stem Cell Research & Therapy. 2013; 4:70. https://doi.org/10.1186/scrt221

Wei L. Angiogenesis and stem cell transplantation as potential treatments of cerebral ischemic stroke. Pathophysiology. 2005; 12:47– 63. https://doi.org/10.1016/j.pathophys.2004.11.002

Schwartz R, Chair, AAT Neuromusculoskeletal Guidelines Committee. Guidelines for Neuromusculoskeletal Infrared Thermography Sympathetic Skin Response (SSR) Studies. The American Academy of Thermology, 2012.

Schwartz R. Sympathetic Skin Response Studies; Harvard Medical School’s online medical text, July, 2007; http://www.wikidoc.org

Getson P. The Use of Thermography in the Diagnosis of CRPS: A Physician's Opinion. The Pain Practitioner. 2006;16(1):72-73.

Aker K. CRPS Diagnosis: A Review of Diagnostic Tests. RSDSA Review Digest, Winter 2008.

Tateishi-Yuyama E. Therapeutic angiogenesis for patients with limb ischaemia by autologous transplantation of bone marrow cell: a pilot study and a randomized controlled trial. The Lancet. 2002;360:427-35. https://doi.org/10.1016/S0140-6736(02)09670-8

Lawall H. Stem Cell and progenitor cell therapy in peripheral artery disease. Thrombosis and Haemostasis. 2010;103:1-13. https://doi.org/10.1160/TH09-10-0688