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Autofagia e sua Relação com Carcinoma de Células Escamosas Oral

DOI: http://dx.doi.org/10.15600/2238-1236/fol.v25n2p31-40

https://www.metodista.br/revistas/revistas-unimep/index.php/FOL/index 

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Marayza A. Clementino1, Hellen B. P. Santos2, Simone A. Sousa3, Pollianna M. Alves4, Gustavo P. Godoy4 & Cassiano F. W. Nonaka4

 

Resumo: Introdução: Estudos apontam para a importância da autofagia na regulação do desenvolvimento e progressão de diversas neoplasias malignas, incluindo o carcinoma de células escamosas oral (CCEO), e na determinação da resposta à terapia anticâncer. Objetivo: Realizar uma revisão de literatura sobre o processo de autofagia e sua relação com CCEO. Métodos: Foi realizada a busca eletrônica de publicações nas bases de dados Web of Science, PubMed e Scopus, utilizando as seguintes palavras-chave, obtidas de acordo com o Medical Subject Headings (MeSH): câncer, câncer bucal, autofagia, proteínas relacionadas à autofagia e carcinoma de células escamosas oral. Os estudos foram divulgados no período de janeiro de 2001 a fevereiro de 2015. Conclusão: A autofagia é um processo que pode estar envolvido no desenvolvimento e progressão do CCEO. Os resultados apresentados pelos trabalhos existentes na literatura sobre o assunto são divergentes, ora sugerindo uma função pró-tumoral ora uma atividade antitumoral para a autofagia nos CCEOs.

Palavras-chave: autofagia; carcinoma de células escamosas; neoplasias bucais.

 

Abstract: Introduction: Studies highlight the importance of autophagy in the regulation of the development and progression of several malignancies, including the oral squamous cell carcinoma (OSCC), and in the determination of the response to the anticancer therapy. Objective: to perform a literature review on the process of autophagy and its relationship with OSCC. Methods: An electronic search of publications was performed in Web of Science, PubMed, and Scopus databases using the following keywords, obtained according to the Medical Subject Headings (MeSH): cancer, oral cancer, autophagy, autophagy-related proteins, and oral squamous cell carcinoma. The studies were published between January 2001 and February 2015. Conclusion: Autophagy is a process that may be involved in the development and progression of OSCC. The results of the studies in the literature on the subject are divergent: some of them suggest a protumor function, others suggest an anti-tumor activity for autophagy in OSCC.

Key words: autophagy; squamous cell carcinoma; oral neoplasms.

 

1 Doutoranda – Programa de Pós-Graduação em Odontologia – Universidade Estadual da Paraíba – UEPB – Campina Grande – PB
2 Mestranda – Programa de Pós-Graduação em Odontologia – Universidade Estadual da Paraíba – UEPB – Campina Grande – PB- Brasil
3 Professora Doutora - Departamento de Clínica e Odontologia Social - Universidade Federal da Paraíba - UFPB - João Pessoa – PB- Brasil
4 Professores Doutores – Programa de Pós-Graduação em Odontologia – Universidade Estadual da Paraíba – UEPB – Campina Grande – PB – Brasil

 

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